Endocrine Abstracts

Introduction: Central diabetes insipidus is a rare condition that typically manifests as polyuria-polydipsia syndrome. Polydipsia helps to maintain normal natremia. Herein, we report the case of persistent hypernatremia in a patient admitted for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.Observation : A 53-year-old woman was referred to our department for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome...

Introduction: Leydig cell tumor is rare, accounting for 1% of testicular tumors. Klinefelter syndrome is most often associated with extra-gonadal germ cell tumors. Its association with testicular tumors remains less frequent. Herein, we report the case of a Leydig cell tumor of the testis in a patient with Klinefelter syndrome.Observation: A 46-year-old man was referred to our department for hypogonadism. His past medical history included type 2 diabetes...

Liver dysfunction is common in patients with hyperthyroidism. The underlying mechanisms remain unclear. Predictors of liver dysfunction and recovery are controversial. The aim of this study was to assess the prevalence of elevated liver enzymes in patients with uncontrolled hyperthyroidism and to identify its predictive factors.Methods: This is a retrospective study conducted in 131 patients with hyperthyroidism admitted in the endocrinology department o...

Introduction: Primary hypothyroidism is a common condition. Its treatment is simple and consists of daily levothyroxine intake. Cases with refractory hypothyroidism despite high doses of levothyroxine were reported. Herein, we report the case of a patient with refractory hypothyroidism secondary to gastrointestinal malabsorption that was improved by L-thyroxine liquid oral substitution.Observation: A 49-year-old woman was admitted for refractory hypothyr...

Introduction: Poorly-controlled hypothyroidism is frequently associated with sleep disorders such as impaired sleep quality and obstructive sleep apnea. The aim of this study was to evaluate the sleep quality in patients with well-controlled primary hypothyroidism.Methods: This was a single-center, cross-sectional study including 50 patients with well-controlled primary hypothyroidism (TSH level within the normal range: 0.35-4.94 mIU/l) for at least one ...

Introduction: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome predisposing to a variety of highly vascularised tumors in different organs. Although bilateral pheochromocytoma was reported in patient with VHL disease, the coexistence of primary hyperparathyroidism is not a common condition. Herein we report a case of a primary hyperparathyroidism secondary to an ectopic secretion of intact parathyroid hormone (PTH) in a patient with VHL disease and b...

Introduction: Osteogenesis imperfecta also known as Lobstein’s disease (LD) is a rare disorder of type 1 collagen characterized by an increased susceptibility to bone fractures. Its coexistencewith primary hyperparathyroidism (PHP) was rarely described. Herein we report a new case of a primary hyperparathyroidismin a patient with a history of Lobstein’s disease.Observation: A 35-year-old woman was referred to our departmentfor hypercalcemia. He...

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

Introduction: The main objective in the management of primary hypothyroidism is to normalize thyrotropin (TSH) level with Levothyroxine replacement therapy. The optimal dose of Levothyroxine may be affected by several factors such as age, gender, body weight, some medical disorders and drugs intake. The aim of this study was to assess the relationship between thyroid antibody titers and Levothyroxine dose in patients with primary hypothyroidism secondary to Hashimoto thyroidit...